Of the 28,723 citations retrieved in the database search, 1,978 full-text articles were reviewed, 411of which were randomized controlled trials evaluating the efficacy of 15 purported dietary supplements, therapies, or a combination thereof. Risk of bias and sufficiency of data varied widely. Few studies (n = 52 [16.5%]) were classified as low risk and sufficient to support efficacy. Of these, only 16 (31%) noted significant pre/post intergroup differences in weight (range: 0.3-4.93 kg).
Dietary supplements and alternative therapies for weight loss have a limited high-quality evidence base of efficacy. More deep reviews published on https://www.hfrreviews.com. Practitioners and patients should be aware of the scientific evidence of claims before recommending use.
